BDBM350323 (S)-3-(1-((1-acryloylpyrrolidin-2-yl)methoxy)isoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one::US10307414, Example 7::US9801872, Example 7

SMILES C=CC(=O)N1CCC[C@H]1COc1nc(cc2ccccc12)-c1n[nH]c(=O)[nH]1

InChI Key InChIKey=LJWJTZQRGMIPDK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350323   

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350323((S)-3-(1-((1-acryloylpyrrolidin-2-yl)methoxy)isoqu...)
Affinity DataIC50: 10nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350323((S)-3-(1-((1-acryloylpyrrolidin-2-yl)methoxy)isoqu...)
Affinity DataIC50: 10nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent