BDBM350245 US10208056, Compound 72

SMILES NC(=O)c1cc2[C@@H](Oc3cnccc3-c2[nH]1)C1CCOCC1

InChI Key InChIKey=QXGOBEONKUXLNG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350245   

TargetCyclin-C/Cyclin-dependent kinase 8(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350245(US10208056, Compound 72)
Affinity DataIC50: 4.46nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetSerine/threonine-protein kinase haspin(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350245(US10208056, Compound 72)
Affinity DataIC50: 406nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
F.S.P. Cnio

US Patent
LigandPNGBDBM350245(US10208056, Compound 72)
Affinity DataIC50: 14.2nMAssay Description:The binding assay relies on the LanthaScreen Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent