BDBM350165 4-[8-amino-1-(4-{(1R)-1- [3-(difluoromethyl)phenyl]- 1- hydroxyethyl}phenyl)imidazo [1,5-a]pyrazin-3-yl]-1,4- dimethylcyclohexane- carboxylic acid::US10208047, Example 33

SMILES C[C@@](O)(c1ccc(cc1)-c1nc(n2ccnc(N)c12)C1(C)CCC(C)(CC1)C(O)=O)c1cccc(c1)C(F)F

InChI Key InChIKey=SOTLKDLBKKWATH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350165   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350165(US10208047, Example 33 | 4-[8-amino-1-(4-{(1R)-1- ...)
Affinity DataIC50: 11.4nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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