BDBM350159 (1S,3R)-3-[8-amino-1-(4- {(1R)-1-[3- (difluoromethyl)phenyl]-1- hydroxyethyl}phenyl)imidazo [1,5-a]pyrazin-3-yl]- 1,2,2- trimethylcyclopentane- carboxylic acid::US10208047, Example 27

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@](C)(C(O)=O)C2(C)C)n2ccnc(N)c12)c1cccc(c1)C(F)F

InChI Key InChIKey=IXKGSENIBWVWIY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350159   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350159(US10208047, Example 27 | (1S,3R)-3-[8-amino-1-(4- ...)
Affinity DataIC50: 0.780nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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