BDBM350151 4-(8-amino-1-{2-ethoxy-4- [1-hydroxy-1-(3- methylphenyl)ethyl]phenyl} imidazo[1,5-a]pyrazin-3- yl)bicyclo[2.2.2]octane-1- carboxylic acid::US10208047, Example 19::US10208047, Example 20

SMILES CCOc1cc(ccc1-c1nc(n2ccnc(N)c12)C12CCC(CC1)(CC2)C(O)=O)C(C)(O)c1cccc(C)c1

InChI Key InChIKey=SYIFQIVJBMBYNN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350151   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350151(US10208047, Example 19 | 4-(8-amino-1-{2-ethoxy-4-...)
Affinity DataIC50: 4.10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350151(US10208047, Example 19 | 4-(8-amino-1-{2-ethoxy-4-...)
Affinity DataIC50: 136nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent