BDBM350147 (1R,3S)-3-[8-amino-1-(4- {(1S)-1-hydroxy-1-[3- (trifluoromethyl)phenyl] ethyl}phenyl)imidazo[1,5- a]pyrazin-3-yl]-1-(1- methylethyl)cyclohexane- carboxylic acid::US10208047, Example 15

SMILES CC(C)[C@]1(CCC[C@@H](C1)c1nc(-c2ccc(cc2)[C@](C)(O)c2cccc(c2)C(F)(F)F)c2c(N)nccn12)C(O)=O

InChI Key InChIKey=AAPXQEUSUAUPKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350147   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350147(US10208047, Example 15 | (1R,3S)-3-[8-amino-1-(4- ...)
Affinity DataIC50: 104nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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