BDBM350086 3-[3-[4-[dideuterio-(trideuteriomethylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine ::US10208027, Compound II-2
SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C
InChI Key InChIKey=JZCWLJDSIRUGIN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 350086
Affinity DataKi: 0.00800nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 74nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 85nMAssay Description:Inhibition of human full length recombinant ATM using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of PI3K alpha (unknown origin) by kinase profiler analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
TargetDNA-dependent protein kinase catalytic subunit(Human)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human full length recombinant DNA-PK using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human full length recombinant mTOR measured after 40 mins in presence of [gamma-33P]ATP by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars