BDBM350019 6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- pyrazol-4-yl)pyrazin-2- yl)-2-(3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2-trifluoroacetate salt::US10208024, Example 18::US10766881, Example 18

SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(C)(C)O)c1

InChI Key InChIKey=KHTGGYNVCUTUEK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350019   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 47.7nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 8.5nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 8.70nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 47.7nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetFibroblast growth factor receptor 2 [403-822](Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 8.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [397-806](Human)
Array Biopharma

US Patent
LigandPNGBDBM350019(6-(3-amino-6-(1-(2- hydroxy-2- methylpropyl)-1H- p...)
Affinity DataIC50: 8.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent