BDBM349959 5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10208020, Example 49::US11638707, Example C15.

SMILES Nc1nnc([nH]1)N1CCC(CC1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccc(Cl)cc1

InChI Key InChIKey=FMVOJJFOZGTECJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349959   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349959(5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

LigandPNGBDBM349959(5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[...)
Affinity DataIC50: 5.50E+3nMAssay Description:Fluorescence polarization assay based on the principle of fluorescence polarization where a red-shifted fluorescent tracer is displaced from the hERG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349959(5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[...)
Affinity DataIC50: 5.50E+3nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent