BDBM349957 (3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)pyrrolidin-3-ol ::US10208020, Example 47::US10538508, Example 47::US11638707, Example C14.::US9944624, Ex. 47

SMILES Nc1nnc([nH]1)N1CCC(CC1)N1C[C@@H](O)C[C@@H]1Cc1ccc(Cl)cc1

InChI Key InChIKey=QOFUCKFXNXPKSV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 349957   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 1.75E+4nMAssay Description:Fluorescence polarization assay based on the principle of fluorescence polarization where a red-shifted fluorescent tracer is displaced from the hERG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent