BDBM349943 5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-isobutyl-4-methylpiperazin-1-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10208020, Example 33::US11638707, Example C12.

SMILES CC(C)C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CN1C)C1CCN(CC1)c1nnc(N)[nH]1

InChI Key InChIKey=RCGRIXXPKNDBJW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349943   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349943(5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-isobutyl-4-meth...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

LigandPNGBDBM349943(5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-isobutyl-4-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Fluorescence polarization assay based on the principle of fluorescence polarization where a red-shifted fluorescent tracer is displaced from the hERG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349943(5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-isobutyl-4-meth...)
Affinity DataIC50: 5.50E+3nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent