BDBM349913 (S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10208020, Example 3::US10538508, Example 3::US9944624, Ex. 3

SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CCOCC1Cc1ccc(Br)cc1

InChI Key InChIKey=CDYQBZJWGZGZKD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 349913   

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
Go to US Patent

TargetAcidic mammalian chitinase(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
Go to US Patent