BDBM349662 2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy}pyridin-2-yl)piperidin-1-yl]methyl}-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid::US10208019, Example 1A-09::US10208019, Example 4A-01

SMILES c1cc(nc(c1)OCc2ccc(cc2F)C#N)C3CCN(CC3)Cc4nc5ccc(cc5n4C[C@@H]6CCO6)C(=O)O

InChI Key InChIKey=HYBAKUMPISVZQP-UHFFFAOYSA-N

Data  2 KI  3 IC50  14 EC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 349662   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of hERG ion channel by patch-clamp methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

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Date in BDB:
6/25/2023
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Astrazeneca

US Patent

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataIC50: 2.00E+3nMAssay Description:Evaluation of the effects of compounds on the activity of the human phosphodiesterase-3A is quantified by measuring the formation of 5′AMP from cAMP ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
6/30/2025
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  13nMAssay Description:Displacement of [125I]-GLP1 from GLP-1 receptor (unknown origin) expressed in CHO cells membrane pre-incubated for 10 mins followed by [125I]-GLP1 ad...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/19/2024
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

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In Depth
Date in BDB:
12/17/2024
Entry Details
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TargetGlucagon-like peptide 1 receptor(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50: >2.00E+4nMAssay Description:Activation of mouse GLP-1R expressed in CHO cells assessed as increase in cAMP accumulationMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
6/25/2023
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TargetGlucagon-like peptide 1 receptor(Rat)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50: >2.00E+4nMAssay Description:Activation of rat GLP-1R expressed in CHO cells assessed as increase in cAMP accumulationMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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Date in BDB:
6/25/2023
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  490nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

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Date in BDB:
6/25/2023
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  760nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-1 cell assessed as induction of beta-arrestin 1 recruitment incub...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  0.950nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/21/2019
Entry Details
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PDB3D Structure (crystal)
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  13nMAssay Description:Agonist activity at GLP-1R (unknown origin) expressed in candidate selection CHO cells assessed as cAMP accumulation incubated for 30 mins by plate r...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  230nMAssay Description:Agonist activity at FAP-tagged human GLP-1R expressed in HEK293 cells assessed as receptor internalizationMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader met...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  0.710nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in presence of BETP by BETP sensitized...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  12nMAssay Description:Displacement of [125I]GLP-1 from human GLP-1R (7 to 36 residues) expressed in HEK293 or CHO cell membranes after 120 mins by radioligand binding assa...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/20/2021
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  13nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/21/2019
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PDB3D Structure (crystal)
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  1.10nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/21/2019
Entry Details
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PDB3D Structure (crystal)
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataEC50:  17nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/21/2019
Entry Details
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PDB3D Structure (crystal)
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataKi:  80nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
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TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

Curated by ChEMBL

LigandBDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)Copy SMILESCopy InChI

Affinity DataKi:  360nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
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