BDBM349324 US10207991, Ex. Cpd. No. 8::US10611728, Example Compound 8::US11691947, Example 8

SMILES COc1cc(CC[C@@H](C)N2Cc3cccc(F)c3C2)ccc1O

InChI Key InChIKey=YYNYULNQESTNGR-UHFFFAOYSA-N

Data  9 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 349324   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataIC50: 7.00E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  41nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  41nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  41nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  41nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  79nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  79nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  79nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  79nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Cognition Therapeutics

US Patent
LigandPNGBDBM349324(US10207991, Ex. Cpd. No. 8 | US10611728, Example C...)
Affinity DataKi:  79nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent