BDBM348971 N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phenyl)-[1,2,4]triazolo[l,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 88

SMILES Fc1cccc(CCS(=O)(=O)Nc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1

InChI Key InChIKey=TZRBRDZIXMXCSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 348971   

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM348971(N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM348971(N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phen...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM348971(N-(5-(4-(2-(3- fluorophenyl)ethylsulfonamido) phen...)
Affinity DataIC50: 300nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent