BDBM348934 N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- 1H-pyrazol-3- yl)methoxy)phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 48

SMILES Cn1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)n1

InChI Key InChIKey=KBZOVNLFRJKVBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 348934   

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM348934(N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

LigandPNGBDBM348934(N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154](Human)
Galapagos

US Patent
LigandPNGBDBM348934(N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...)
Affinity DataIC50: 100nMAssay Description:Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Galapagos

US Patent
LigandPNGBDBM348934(N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...)
Affinity DataIC50: 300nMAssay Description:Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent