BDBM347646 4-methyl-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl]ethynyl]quinoline::US9790203, Example 16

SMILES Cc1cc(nc2ccccc12)C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1

InChI Key InChIKey=VMGUUOVEQWNGRC-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347646   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Abbvie

US Patent

LigandBDBM347646(4-methyl-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL