BDBM347639 4-(1-methyl-3-(4-((1-methyl-1H-imidazol-2-yl)ethynyl)phenyl)-1H-pyrazole-4-yl)pyridine::US9790203, Example 7

SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1nccn1C)-c1ccncc1

InChI Key InChIKey=VOTPUSFVQRQNKT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347639   

LigandPNGBDBM347639(4-(1-methyl-3-(4-((1-methyl-1H-imidazol-2-yl)ethyn...)
Affinity DataIC50: 100nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM347639(4-(1-methyl-3-(4-((1-methyl-1H-imidazol-2-yl)ethyn...)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant PDE10A (unknown origin) using cAMP/cGMP as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed