BDBM347462 3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US10435361, Example 3::US9790174, Example 3

SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(c4)C(=O)NCCOCCOCCOC)c3)c3ccccc23)c1OC)C(C)(C)C

InChI Key InChIKey=KVZWIKQTZBIQFZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 347462   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 87nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
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Date in BDB:
9/9/2019
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 20nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/9/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 692nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 4.32E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 87nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 20nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Respivert

US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 692nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Respivert

US Patent
LigandPNGBDBM347462(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsu...)
Affinity DataIC50: 4.32E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent