BDBM346302 US10202377, Compound 202

SMILES Cc1cn(cn1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(NC(=O)C2CCC2)c1

InChI Key InChIKey=PHSYKNAWSJRUNC-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346302   

TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM346302(US10202377, Compound 202)
Affinity DataIC50: 63.2nMAssay Description:The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetTGF-beta receptor type-1(Human)
Samumed

US Patent
LigandPNGBDBM346302(US10202377, Compound 202)
Affinity DataEC50:  9nMAssay Description:Compound Screening: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:2, 11-point d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent