BDBM346174 US10202371, Example 4

SMILES CC[C@H]1[C@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1ccccc1

InChI Key InChIKey=QPCPSPSSGSDMCQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 346174   

LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 47nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 159nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 66nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 4.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 9.70E+3nMAssay Description:TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 597nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 757nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346174(US10202371, Example 4)
Affinity DataIC50: 298nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent