BDBM345819 US10202362, Compound T2.2

SMILES OC(=O)c1ccc(CN2CCCC(CNc3ccc(Oc4ccc(Cl)cc4)cc3)C2)cc1

InChI Key InChIKey=ZFTSPYMTXLAPOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345819   

TargetLeukotriene A-4 hydrolase(Human)
Celtaxsys

US Patent
LigandPNGBDBM345819(US10202362, Compound T2.2)
Affinity DataIC50: 1.80nMAssay Description:LTB4 formed was quantified with the HTRF assay in which free LTB4 competes with LTB4-XL665 conjugate (acceptor) for anti-LTB4 monoclonal antibody lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetDipeptidyl peptidase 1(Human)
Celtaxsys

US Patent
LigandPNGBDBM345819(US10202362, Compound T2.2)
Affinity DataIC50: 22nMAssay Description:In brief, the enzyme (29 nM) was incubated with L-alanine-p-nitroanilide (1 mM) in 50 mM HEPES (pH 7.5), 100 mM KCL, 1% DMSO in the absence or presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent