BDBM345466 Propane-2-sulfonic acid [2-(2- cyano-6-methoxy-phenoxy)-6-(1,5- dimethyl-6-oxo-1,6-dihydro-pyridin- 3-yl)-pyrimidin-4-yl]-amide::US10202360, Example 11

SMILES COc1cccc(C#N)c1Oc1nc(NS(=O)(=O)C(C)C)cc(n1)-c1cc(C)c(=O)n(C)c1

InChI Key InChIKey=XGNAHVWKSRAKDT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 345466   

TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345466(US10202360, Example 11 | Propane-2-sulfonic acid [...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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TargetCREB-binding protein(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345466(US10202360, Example 11 | Propane-2-sulfonic acid [...)
Affinity DataIC50: 500nMAssay Description:Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM345466(US10202360, Example 11 | Propane-2-sulfonic acid [...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BRD4 was determined as previously described in U.S. Pat. No. 9,034,900.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent