BDBM34545 MLS000104342::N-(2-pyridinyl)-2-pyridinecarbothioamide::N-(2-pyridyl)thiopicolinamide::N-pyridin-2-ylpyridine-2-carbothioamide::SMR000054277::cid_750538

SMILES S=C(Nc1ccccn1)c1ccccn1

InChI Key InChIKey=UGWOJXZJIZUKDP-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 34545   

TargetTranscription factor p65(Human)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataEC50:  2.03E+3nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of Atg4B (unknown origin) using LC3B-GST as substrate preincubated for 24 hrs followed by substrate addition measured for 3 mins by SDS-PA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of ATG4B (unknown origin) using LC3B-GST as substrate preincubated for 24 hrs followed by substrate addition measured after 3 mins by SDS-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of ATG4B (unknown origin) using GST-labelled LC3B as substrate after 24 hrs followed by substrate addition and measured after 3 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of ATG4B in human SAOS-2 cells using GFP-LC3B as substrate incubated for 6 hrs by by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant ATG4B (unknown origin) using pim-FG-PABA-AMC as substrate by fluoroscence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCysteine protease ATG4B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM34545(MLS000104342 | N-pyridin-2-ylpyridine-2-carbothioa...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ATG4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed