BDBM345108 4-[(2-{5-[5-chloro-2-(1H- 1,2,3-triazol-1-yl)phenyl]- 1-oxidopyridin-2-yl}-3- cyclopropylpropanoyl) amino]benzoic acid::US9783530, 54

SMILES OC(=O)c1ccc(NC(=O)C(CC2CC2)c2ccc(c[nH+]2)-c2cc(Cl)ccc2-n2ccnn2)cc1

InChI Key InChIKey=LRUDFXHPVCNXTP-UHFFFAOYSA-O

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345108   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM345108(4-[(2-{5-[5-chloro-2-(1H- 1,2,3-triazol-1-yl)pheny...)
Affinity DataIC50: 4.70nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
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TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM345108(4-[(2-{5-[5-chloro-2-(1H- 1,2,3-triazol-1-yl)pheny...)
Affinity DataIC50: 678nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent