BDBM345064 4-({[5-(3-chloro-2,6- difluorophenyl)-1- oxidopyridin-2- yl]acetyl}amino) benzoic acid::US9783530, 9

SMILES OC(=O)c1ccc(NC(=O)Cc2ccc(c[n+]2[O-])-c2c(F)ccc(Cl)c2F)cc1

InChI Key InChIKey=CXXYYWYZQYNKRT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 345064   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM345064(4-({[5-(3-chloro-2,6- difluorophenyl)-1- oxidopyri...)
Affinity DataIC50: 89.2nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
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TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM345064(4-({[5-(3-chloro-2,6- difluorophenyl)-1- oxidopyri...)
Affinity DataIC50: 1.57E+3nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
Go to US Patent