BDBM344747 1-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]-3-[1-(2-fluorophenyl)-1H-indazol-4-yl]imidazolidin-2-one::US9783527, Example 49

SMILES Fc1ccccc1-n1ncc2c(cccc12)N1CCN(Cc2nnc(o2)C2CC2)C1=O

InChI Key InChIKey=XAOIOZZLQMVEHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 344747   

LigandPNGBDBM344747(1-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]-3-[...)
Affinity DataIC50: 538nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.8 (Essen, Ann Arbor, Mich.) were quickly thawed and pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Abbvie

US Patent
LigandPNGBDBM344747(1-[(5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl]-3-[...)
Affinity DataIC50: 2.32E+3nMAssay Description:Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent