BDBM344704 Compound 74::US9783524, Example 74

SMILES COc1cc(N2CCN(C)CC2)c(NC(=O)C=C)cc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(=O)N(C)C)n1

InChI Key InChIKey=VMFMUJZRXZXYAH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 344704   

TargetALK tyrosine kinase receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM344704(Compound 74 | US9783524, Example 74)
Affinity DataIC50: 9.33nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM344704(Compound 74 | US9783524, Example 74)
Affinity DataIC50: 15.5nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM344704(Compound 74 | US9783524, Example 74)
Affinity DataIC50: 15.8nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM344704(Compound 74 | US9783524, Example 74)
Affinity DataIC50: 422nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM344704(Compound 74 | US9783524, Example 74)
Affinity DataIC50: 513nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent