BDBM344692 3-[(2S)-4-[(3-chloro-4- fluorophenyl)sulfonyl]-8- fluoro-6-{[(2,2,2-trifluoro- 1,1- dimethylethoxy)carbonyl]ami- no}-3,4-dihydro-2H-1,4- benzoxazin-2-yl]propanoic acid::US9783511, 29F

SMILES CC(C)(OC(=O)Nc1cc(F)c2O[C@@H](CCC(O)=O)CN(c2c1)S(=O)(=O)c1ccc(F)c(Cl)c1)C(F)(F)F

InChI Key InChIKey=RGTIDCHZJCTDQO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344692   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM344692(3-[(2S)-4-[(3-chloro-4- fluorophenyl)sulfonyl]-8- ...)
Affinity DataIC50: 5.70nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details
Go to US Patent