BDBM344442 Preparation of (S)-3-(4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid (4)::US9783511, 4

SMILES CC(C)(OC(=O)Nc1ccc2O[C@@H](CCC(O)=O)CN(c2c1)S(=O)(=O)c1ccc(F)c(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=WHVVNZCGWIUCPQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344442   

TargetNuclear receptor ROR-gamma(Human)
Lycera

US Patent
LigandPNGBDBM344442(Preparation of (S)-3-(4-((4-fluoro-3-(trifluoromet...)
Affinity DataIC50: 6nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details
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