BDBM34422 1-{[6-(2,3-dihydro-1,4-benzodioxin-6-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole::3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::3-(benzotriazol-1-ylmethyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::MLS000052394::SMR000081761::cid_2231443

SMILES C(c1nnc2sc(nn12)-c1ccc2OCCOc2c1)n1nnc2ccccc12

InChI Key InChIKey=ZDFSRZOEMLNZQI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 34422   

TargetGag-Pol polyprotein(HIV-1)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 1.69E+3nMpH: 8.0 T: 2°CAssay Description:A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2009
Entry Details
PCBioAssay
TargetDiphosphomevalonate decarboxylase(Streptococcus pneumoniae D39)
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 8.38E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetPolyadenylate-binding protein 1(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 6.60E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetPolyadenylate-binding protein 1(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 6.60E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34422(3-(1-benzotriazolylmethyl)-6-(2,3-dihydro-1,4-benz...)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed