BDBM343751 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl-1H-benzo[d]imidazol-6-yl)phenoxy)propan-2-ol::US9777008, Compound 45

SMILES Cn1cnc2ccc(cc12)-c1cccc(OCC(O)CN2CCc3ccccc3C2)c1

InChI Key InChIKey=XOQLCVLZWLEHOX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 343751   

LigandPNGBDBM343751(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl...)
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
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LigandPNGBDBM343751(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM343751(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl...)
Affinity DataIC50: 435nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed