BDBM3437 1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea::1-[2-amino-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 19::PD089828 analog 8

SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Br)cccc1Br

InChI Key InChIKey=BLWHUHULXVDXMZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 3437   

LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 1.40E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 290nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 210nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 1.42E+3nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 290nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 210nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3437(1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido-[2,3-d]py...)
Affinity DataIC50: 1.42E+3nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article