BDBM34300 3-(1-benzotriazolylmethyl)-6-(phenylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::3-(benzotriazol-1-ylmethyl)-6-benzyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::MLS000042629::SMR000048030::cid_666637

SMILES C(c1nn2c(Cn3nnc4ccccc34)nnc2s1)c1ccccc1

InChI Key InChIKey=MNNKRGMSLHQOQF-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 34300   

TargetGag-Pol polyprotein(HIV-1)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataIC50: 1.84E+3nMpH: 8.0 T: 2°CAssay Description:A fluorescence resonance energy transfer assay is developed in 96-well and 384-well microplate formats with robotic manipulation to enable high-throu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2009
Entry Details
PCBioAssay
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataIC50: 4.88E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM34300(3-(benzotriazol-1-ylmethyl)-6-(phenylmethyl)-[1,2,...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed