BDBM342895 1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-pyrimidinyl-6-isoquinolinesulfonamide::US9776995, Example 108

SMILES COc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncccn1)-c1cccc(F)c1

InChI Key InChIKey=DUWRTDJSNRFMAI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 342895   

LigandPNGBDBM342895(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-...)
Affinity DataIC50: 86.2nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details
Go to US Patent

LigandPNGBDBM342895(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342895(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed
LigandPNGBDBM342895(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed
LigandPNGBDBM342895(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-2-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed