BDBM342448 N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)-yl]- 1,3-thiazol-4-yl}-5-methoxy- 3-methylpyrazine-2- carboxamide::US9771379, Example 23

SMILES COc1cnc(C(=O)Nc2csc(n2)[C@]23CO[C@H](C[C@H]2COC(N)=N3)C(F)(F)F)c(C)n1

InChI Key InChIKey=CJLQIZQQBHPNBX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342448   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342448(US9771379, Example 23 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 162nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent