BDBM342445 N-{2-[(4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)- yl]-1,3-thiazol-4-yl}-5- (difluoromethoxy)pyrazine- 2-carboxamide::US9771379, Example 20

SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CO1)C(F)(F)F)c1nc(NC(=O)c2cnc(OC(F)F)cn2)cs1

InChI Key InChIKey=KSSFNOIVJFQWMQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342445   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342445(US9771379, Example 20 | N-{2-[(4aR,6R,8aR)-2- amin...)
Affinity DataIC50: 124nMAssay Description:The BACE1 binding assay measured beta-site amyloid precursor protein-cleaving enzyme (BACE) binding as a decrease in the counts of radioligand bound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent