BDBM342440 N-(2-((4a′R,8a′R)-2′-amino-4a′,5′-dihydro-4′H-spiro[cyclobutane-1,6′-pyrano[3,4-d][1,3]oxazin]-8a′(8′H)-yl)thiazol-4-yl)-5-(difluoromethoxy)-3-methyl picolinamide::US9771379, Example 15

SMILES Cc1cc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12COC3(CCC3)C[C@H]1COC(N)=N2

InChI Key InChIKey=YLFORLVDZPJUDS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342440   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342440(US9771379, Example 15 | N-(2-((4a′R,8a′...)
Affinity DataIC50: 370nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
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