BDBM342436 N-(2-((4aS,6S,8aS)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)- yl)thiazol-4-yl)-3-chloro-5- (difluoromethoxy) picolinamide::US9771379, Example 13b

SMILES NC1=N[C@@]2(CO[C@@H](C[C@@H]2CO1)C(F)(F)F)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)cs1

InChI Key InChIKey=AXOMWSFAEGDUQS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342436   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342436(US9771379, Example 13b | N-(2-((4aS,6S,8aS)-2- ami...)
Affinity DataIC50: 6.97E+3nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent