BDBM342432 N-(2-((4aR,6R,8aR)-2- amino-6-(trifluoromethyl)- 4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)- yl)thiazol-4-yl)-5- (difluoromethoxy)-3- methylpicolinamide::US9771379, Example 11a

SMILES Cc1cc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12CO[C@H](C[C@H]1COC(N)=N2)C(F)(F)F

InChI Key InChIKey=BSPOWBGZMCAKAH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342432   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342432(US9771379, Example 11a | N-(2-((4aR,6R,8aR)-2- ami...)
Affinity DataIC50: 155nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent