BDBM342426 N-(2-((4S,4aR,6S,8aR)-2-amino-6-methyl-4-(trifluoromethyl)-4,4a,5,6-tetrahydropyrano [3,4-d][1,3]oxazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide::US9771379, Example 7

SMILES C[C@H]1C[C@H]2[C@H](OC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1)C(F)(F)F

InChI Key InChIKey=OYZZAKTYLYUPAI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342426   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM342426(US9771379, Example 7 | N-(2-((4S,4aR,6S,8aR)-2-ami...)
Affinity DataIC50: 112nMAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent