BDBM342107 3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 7

SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4C)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C

InChI Key InChIKey=DTBVFMOSIXAFFR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342107   

TargetMitogen-activated protein kinase 12(Human)
Topivert Pharma

US Patent
LigandPNGBDBM342107(US9771353, Example 7 | 3-((4-((4-(3-(3-(tert-Butyl...)
Affinity DataIC50: 11nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM342107(US9771353, Example 7 | 3-((4-((4-(3-(3-(tert-Butyl...)
Affinity DataIC50: 5nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM342107(US9771353, Example 7 | 3-((4-((4-(3-(3-(tert-Butyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM342107(US9771353, Example 7 | 3-((4-((4-(3-(3-(tert-Butyl...)
Affinity DataIC50: 1.85E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
Go to US Patent