BDBM341142 US9765057, 9::methyl 4-(4-methylpiperazin-1-yl)- 2-{[(3R,6R)-6-methyl-1-{[2-(2H- 1,2,3-triazol-2-yl)phenyl]carbonyl}- piperidin-3-yl]oxy}pyridine-3- carboxylate

SMILES COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)nccc1N1CCN(C)CC1

InChI Key InChIKey=RDXSSXVHLNADAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 341142   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50: 1.53E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341142(US9765057, 9 | methyl 4-(4-methylpiperazin-1-yl)- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent