BDBM341140 US9765057, 7::methyl 2-({(3R,6R)-1-[(3-fluoro-2- pyrimidin-2-ylphenyl)carbonyl]-6- methylpiperidin-3-yl}oxy)-4- (methylsulfanyl)pyridine-3- carboxylate

SMILES COC(=O)c1c(SC)ccnc1O[C@@H]1CC[C@@H](C)N(C1)C(=O)c1cccc(F)c1-c1ncccn1

InChI Key InChIKey=DNQIFBHZHDYRSE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 341140   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50: 37.8nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341140(US9765057, 7 | methyl 2-({(3R,6R)-1-[(3-fluoro-2- ...)
Affinity DataIC50: 1.03E+3nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent