BDBM339992 US9776988, Example 18

SMILES CCN1CCN(CC1)c1ccc2[nH]c(nc2c1)-c1cc(CCc2cc(OC)cc(OC)c2)[nH]n1

InChI Key InChIKey=HJJBUHHTOHQWIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 339992   

TargetFibroblast growth factor receptor 2(Human)
Celon Pharma

US Patent
LigandPNGBDBM339992(US9776988, Example 18)
Affinity DataIC50: 2.05nMAssay Description:The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Celon Pharma

US Patent
LigandPNGBDBM339992(US9776988, Example 18)
Affinity DataIC50: 4.72nMAssay Description:The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Celon Pharma

US Patent
LigandPNGBDBM339992(US9776988, Example 18)
Affinity DataIC50: 8.65nMAssay Description:The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Celon Pharma

US Patent
LigandPNGBDBM339992(US9776988, Example 18)
Affinity DataIC50: 81.6nMAssay Description:The compounds were dissolved in 100% DMSO, and obtained solutions were serially diluted in reaction buffer (50 mM Tris pH 7.5, 10 mM MgCl2, 0.25 mM E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent