BDBM339979 5-[(3-aminotetrahydro-2H- pyran-4-yl)amino]-3-(4- chloro-1H-indol-2- yl)pyrazine-2- carboxamide::US9775839, 7.3::US9775839, 7.4

SMILES NC1COCCC1Nc1cnc(C(N)=O)c(n1)-c1cc2c(Cl)cccc2[nH]1

InChI Key InChIKey=WKTJZUOEHAPWIE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 339979   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM339979(US9775839, 7.4 | 5-[(3-aminotetrahydro-2H- pyran-4...)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM339979(US9775839, 7.4 | 5-[(3-aminotetrahydro-2H- pyran-4...)
Affinity DataIC50: 5.90nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent