BDBM339933 6-(((2R,5R,6R)-4-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)-5-(4-chloro-3-fluorophenyl)-6-(3-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid or 6-(((2S,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(4-chloro-3-fluorophenyl)-6-(3-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinic acid::US9758495, 6

SMILES COC(=O)c1ccc(C[C@]2(C)O[C@@H](C(N([C@H](CSC(C)(C)C)C3CC3)C2=O)c2ccc(Cl)c(F)c2)c2cccc(Cl)c2)nc1

InChI Key InChIKey=MJNPIZNGWNFUEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339933   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM339933(US9758495, 6 | 6-(((2R,5R,6R)-4-((S)-2-(tert-Butyl...)
Affinity DataIC50: 0.110nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent