BDBM339742 US10202339, Compound 187

SMILES FC(F)(F)CNS(=O)(=O)c1ccc(OCC2CC2)c(NC(=O)Nc2ncc(Cl)s2)c1

InChI Key InChIKey=BECJSHCXAAXOMM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339742   

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
Agios Pharmaceuticals

US Patent
LigandPNGBDBM339742(US10202339, Compound 187)
Affinity DataIC50: 550nMAssay Description:Compounds were assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds were preincubated with enzyme, then the react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent