BDBM339072 US10201546, Example 27

SMILES CC(C)(C)c1c(\C=C\c2ccccc2)nc2ccc(cc2c1Cl)C(O)(c1cccnc1)c1cccc(Cl)c1

InChI Key InChIKey=HFYJUSZGMWKHTA-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 339072   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM339072(US10201546, Example 27)
Affinity DataKd:  6.60E+3nMAssay Description:ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM339072(US10201546, Example 27)
Affinity DataIC50: 420nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent