BDBM338846 (rac)-N-{3-[4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide (compound 9), N-{3-[(6R)-4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide (compound 10), N-{3-[(6S)-4-amino-6-(fluoromethyl)-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-6-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide ::US9751886, Compound 11

SMILES NC1=N[C@](CF)(Cn2nncc12)c1cc(NC(=O)c2ccc(F)cn2)ccc1F

InChI Key InChIKey=KTMJHDICOAOUQM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 338846   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338846(US9751886, Compound 11 | (rac)-N-{3-[4-amino-6-(fl...)
Affinity DataIC50: 1.00E+9nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338846(US9751886, Compound 11 | (rac)-N-{3-[4-amino-6-(fl...)
Affinity DataIC50: 759nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338846(US9751886, Compound 11 | (rac)-N-{3-[4-amino-6-(fl...)
Affinity DataIC50: 501nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the Swedish Lys-Met/Asn-Leu mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent